Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves
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Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves
The disposition kinetics of levofloxacin was investigated in six male crossbred calves following single intravenous administration, at a dose of 4 mg/kg body weight, into the jugular vein subsequent to a single intramuscular injection of paracetamol (50 mg/kg). At 1 min after the injection of levofloxacin, the concentration of levofloxacin in plasma was 17.2 +/- 0.36 microg/ml, which rapidly de...
متن کاملKinetic disposition, urinary excretion and dosage regimen of subcutaneously administered levofloxacin in cross bred calves
The present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. The concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. Peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...
متن کاملkinetic disposition, urinary excretion and dosage regimen of subcutaneously administered levofloxacin in cross bred calves
the present study was conducted on five healthy male cross bred calves to study the kinetic dispositionand urinary excretion of levofloxacin following its single subcutaneous administration at the dose of4 mg.kg-1. the concentration of levofloxacin in plasma and urine samples was estimated by microbiologicalassay. peak plasma level of levofloxacin (2.8 ± 0.3 μg.ml-1) was observed at 45 min and ...
متن کاملPharmacokinetics, dosage regimen and in vitro plasma protein binding of intramuscular levofloxacin in buffalo calves
The pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. Peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above MIC90 in plasma was detected up to 12 h of administration. The bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1....
متن کاملDisposition Kinetics and Urinary Excretion of Paracetamol Following Intravenous Administration in Buffalo Calves (Bubalus bubalis)
Paracetamol (Acetaminophen), a NSAID is well tolerated and lacks many side effects of aspirin. It is a widely used over-the-counter analgesic, antipyretic and weak anti-in ammatory property. The main mechanism is the inhibition of cyclooxygenase (COX) and recent ndings suggest that it is highly selective for COX-2 (Henz et al., 2008). The present study was aimed to study the disposition kine...
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ژورنال
عنوان ژورنال: Journal of Veterinary Science
سال: 2007
ISSN: 1229-845X
DOI: 10.4142/jvs.2007.8.4.357